抗菌肽:不斷進化的應用
欄目:行業新聞 發布時間:2020-07-01
AMP的高效協同作用
本期文章:《科學》:Volume 368 Issue 6490

德國柏林自由大學Jens Rolff等研究人員總結了抗菌肽的認識和應用前景。這一綜述論文于2020年5月1日發表在國際學術期刊《科學》上。

研究人員表示,抗菌肽(AMP)是多細胞生物免疫防御的重要組成部分,目前正作為抗感染藥進行開發。傳統上認為AMP具有廣譜活性和簡單的動力學,但最近的證據表明,AMP具有出乎意料的特異性和高協同作用能力。

對AMP基因分子進化和群體遺傳的深入評估發現,與以前認為的相比,AMP基因多態性的適應性維持以及AMP活性的適應性丟失更為常見。AMP表現出可降低目標微生物耐藥性進化的藥理動態性質,并且AMP可以彼此協同作用,也可以與常規抗生素協同作用。

這兩個特性使AMP在轉化應用中具有吸引力。研究人員認為,如果要在臨床上使用AMP,了解其天然生物學則至關重要,從而減少附帶損害的風險并避免目前常規抗生素面臨的耐藥性危機。

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附:英文原文
Title: Antimicrobial peptides: Application informed by evolution

Author: Brian P. Lazzaro, Michael Zasloff, Jens Rolff

Issue&Volume: 2020/05/01

Abstract: Antimicrobial peptides (AMPs) are essential components of immune defenses of multicellular organisms and are currently in development as anti-infective drugs. AMPs have been classically assumed to have broad-spectrum activity and simple kinetics, but recent evidence suggests an unexpected degree of specificity and a high capacity for synergies. Deeper evaluation of the molecular evolution and population genetics of AMP genes reveals more evidence for adaptive maintenance of polymorphism in AMP genes than has previously been appreciated, as well as adaptive loss of AMP activity. AMPs exhibit pharmacodynamic properties that reduce the evolution of resistance in target microbes, and AMPs may synergize with one another and with conventional antibiotics. Both of these properties make AMPs attractive for translational applications. However, if AMPs are to be used clinically, it is crucial to understand their natural biology in order to lessen the risk of collateral harm and avoid the crisis of resistance now facing conventional antibiotics.

DOI: 10.1126/science.aau5480

Source: 
https://science.sciencemag.org/content/368/6490/eaau5480


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